What used to be a working-class, immigrant neighborhood, the Lower East Side has been gentrified into an area occupied by young professionals and students. The area was once home to many Eastern European Jewish immigrants, but now is occupied by Polish, Ukrainian, Japanese and Muslim immigrants.

The area stretches from the Bowery to East River Park, with Houston Street beings its northern boundary and Canal Street and East Broadway making up its southern.

Gentrification has made the neighborhood much safer than it once was and it has become a nightlife hotspot with many clubs and bars lining the streets. Popular venues like the Bowery Ballroom and Mercury Lounge are located in the area.

Lower East Side is also home to many delicious restaurants. At 71 Clinton Fresh Food (212-614-6960), 71 Clinton St., patrons can dine on a prix-fixe menu. Or try the oldest delicatessen in New York City, Katz’s Delicatessen (212-254-2246), 205 E. Hudson St., the place where "Harry met Sally."

If considering staying in the area, check in at the Blue Moon Hotel, a smoke-free, 22-guestroom hotel. The Off SoHo Suites Hotel provides roomy accommodations that is a rarity in Manhattan hotels.